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SYNOPSIS

Thirty-two patients with chronic cluster headache, not responding to conventional therapy, were treated with lithium carbonate for 32 weeks.

Treatment was discontinued in 4 cases because of intolerable side effects. Marked and continued improvement occurred in 27 of 28 patients throughout the treatment period. Twenty-five percent of all patients had mild or transient side effects without increased serum lithium levels. Long-term prophylactic lithium maintenance treatment is efficacious in selected cases of chronic cluster headache.