Humoral and Hormonal Changes in Menstrual Migraine

Authors

  • Dr. G. Nattero,

    1. Instituto Di Medicina Insterna, Dell'Universita Di Torino, Cattedra Di Clinica Medica Generale E Terapia Medica II, Via Genova, 3 Italy.
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  • Dr. D. Bisbocci,

    1. Instituto Di Medicina Insterna, Dell'Universita Di Torino, Cattedra Di Clinica Medica Generale E Terapia Medica II, Via Genova, 3 Italy.
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  • Dr. A. Bottini,

    1. Instituto Di Medicina Insterna, Dell'Universita Di Torino, Cattedra Di Clinica Medica Generale E Terapia Medica II, Via Genova, 3 Italy.
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  • Dr. G. Brandi,

    1. Instituto Di Medicina Insterna, Dell'Universita Di Torino, Cattedra Di Clinica Medica Generale E Terapia Medica II, Via Genova, 3 Italy.
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  • Dr. P.G. Griffa,

    1. Instituto Di Medicina Insterna, Dell'Universita Di Torino, Cattedra Di Clinica Medica Generale E Terapia Medica II, Via Genova, 3 Italy.
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  • Dr. F. Lisino,

    1. Instituto Di Medicina Insterna, Dell'Universita Di Torino, Cattedra Di Clinica Medica Generale E Terapia Medica II, Via Genova, 3 Italy.
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  • Dr. A. Ansini,

    1. Instituto Di Medicina Insterna, Dell'Universita Di Torino, Cattedra Di Clinica Medica Generale E Terapia Medica II, Via Genova, 3 Italy.
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  • Dr. F. Ceresa

    1. Instituto Di Medicina Insterna, Dell'Universita Di Torino, Cattedra Di Clinica Medica Generale E Terapia Medica II, Via Genova, 3 Italy.
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  • Presented at the Joint Meeting Ital. - Scandin. Migraine Societies, Florence, Italy, June, 1976.

Abstract

SYNOPSIS

Circadian plasma levels of aldosterone, renin activity, cortisol, sodium and potassium were studied during the migraine attack and headache-free periods in ten women with menstrual migraine. Aldosterone dropped at the onset of an attack in all cases, producing an inverted profile when plotted at two-hourly intervals over a 24-hour period and compared with aldosterone levels during a headache-free period. Renin activity and cortisol levels were normal during migraine and headache-free periods and potassium and sodium were normal during the migraine attack. A possible explanation for the fall in aldosterone during the attack phase is increased conjugation in the liver due to increased hepatic blood flow.

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