Supported by Grant NS 09287 from the National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20014.
Transient Cerebral Ischemia and Brain Serotonin: Relevance to Migraine
Version of Record online: 23 JUN 2005
Headache: The Journal of Head and Face Pain
Volume 17, Issue 4, pages 145–147, September 1977
How to Cite
Welch, K.M.A., Gaudet, R., Wang, T.P.F. and Chabi, E. (1977), Transient Cerebral Ischemia and Brain Serotonin: Relevance to Migraine. Headache: The Journal of Head and Face Pain, 17: 145–147. doi: 10.1111/j.1526-4610.1977.hed1704145.x
Presented in part at the 5th Annual Meeting, Society for Neuroscience, New York City, November 2-6, 1975.
- Issue online: 23 JUN 2005
- Version of Record online: 23 JUN 2005
- Accepted for publication: 62277
- Cited By
Central pain supersensitivity related to depletion of serotonin in the central nervous system has been postulated as a mechanism for migraine. In the present study, transient cerebral ischemia in an animal preparation caused depletion of central nervous system serotonin. Ischemia associated with the prodromal phase of migraine must, therefore, be considered as a possible cause of altered central nervous system serotonin metabolism, possibly leading to increased pain sensitivity