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SYNOPSIS

Use of vasoconstrictor agents for treatment of migraine associated with prolonged neurologic manifestations has been controversial because permanent sequelae, though rare, occur most commonly in these patients. A slowly released form of Papaverine, 150 mg twice a day prevented the premonitory neurologic symptoms in seven patients with complicated migraine. Four of these patients also became headache-free and the remaining three were considerably improved. Papaverine therapy was effective in patients in whom the use of ergotamine or other potent vasoconstrictor agents might be hazardous