Fluphenazine for Tension Headache; Double-Blind Study
Article first published online: 23 JUN 2005
Headache: The Journal of Head and Face Pain
Volume 17, Issue 5, pages 216–218, November 1977
How to Cite
Hakkarainen, H. (1977), Fluphenazine for Tension Headache; Double-Blind Study. Headache: The Journal of Head and Face Pain, 17: 216–218. doi: 10.1111/j.1526-4610.1977.hed1705216.x
- Issue published online: 23 JUN 2005
- Article first published online: 23 JUN 2005
- Accepted for publication: 81777
- Cited By
Fluphenazine, a fluorinated piperazine derivative of phenothiazine was compared with placebo in a double-blind study of 50 patients with tension headache. Daily dose of fluphenazine was 1 mg. The trial was completed by 48 patients. Treatment periods were 2 months each.
Days with headache diminished significantly more during treatment with fluphenazine than placebo (P < 0.001). Duration ot the headache decreased and severity of pain was reduced significantly with fluphenazine. Mean quantities of analgesics used during one headache day was 1.6 on fluphenazine and 2.5 on placebo (P < 0.001). Thirty-six patients considered fluphenazine and one placebo as the superior drug.
Side effects were reported by 19 patients on fluphenazine and 15 on placebo. Two patients interrupted fluphenazine trial because of extrapyramidal dyskinesias.