Twenty-four migraineurs were placed on three diets: A, B, and C for 18 weeks. Diet A foods contained tyramine, exclusive of tyramine-free foodstuff. Diet B patients consumed tyramine-freefoods and excluded those containing tyramine. The Diet C group ate and drank ad-lib. The results showed no significant difference in the severity of migraine in any diet; however, some headaches were time-locked to the ingestion of alcohol, chocolate and fasting. These dietary factors probably do not increase the frequency of headaches but may precipitate them earlier. In general, diet appears to be relatively unimportant in migraine.