Controlled Trials of Cimetidine in Migraine and Cluster Headache

Authors

  • M. Anthony,

    1. From the Division of Neurology, The Prince Henry Hospital and the School of Medicine, University of New South Wales, Sydney, Australia.
    Search for more papers by this author
  • G.D.A. Lord,

    1. From the Division of Neurology, The Prince Henry Hospital and the School of Medicine, University of New South Wales, Sydney, Australia.
    Search for more papers by this author
    • 1Commonwealth Postgraduate Scholar and Sandoz Research Fellow.

  • J.W. Lance

    1. From the Division of Neurology, The Prince Henry Hospital and the School of Medicine, University of New South Wales, Sydney, Australia.
    Search for more papers by this author

Abstract

SYNOPSIS

Controlled double-blind trials of the histamine H2-receptor antagonist, cimetidine, alone and in combination with the histamine H1-receptor antagonist, chlorpheniramine, in 24 patients with migraine and 20 patients with cluster headache, showed that these agents were ineffective in prophylaxis. The reason for this may lie in the fact that induced intracellular histamine does not act via receptors and does not necessarily negate the hypothesis that histamine plays a role in the pathogenesis of vascular headaches.

Ancillary