HLA Antigens in Migraine

Authors

  • Brian P. O'Neill M.D.,

    1. Department of Neurology, University of Michigan Medical Center, Ann Arbor VA Hospital, Ann Arbor, MI and
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  • Janet J. Kapur B.A., M. T. (ASCP),

    1. Department of Histocompatibility Research Laboratory, University of Michigan Medical Center, Ann Arbor VA Hospital, Ann Arbor, MI.
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  • Armin E. Good M.D.

    1. Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor VA Hospital, Ann Arbor, MI;
    2. Department of Rheumatology Services, University of Michigan Medical Center, Ann Arbor VA Hospital, Ann Arbor, MI and the
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  • Funded through the Medical Research Service, VA Hospital, Ann Arbor, MI.

Abstract

SYNOPSIS

Fifty consecutive patients with migraine headaches were evaluated for the presence of 10 HLA-A and 14 HLA-B antigens by means of the microlymphocytotoxicity assay. Comparisons were made between classical and common migraine, and between patients with and without a family history of migraine. All groups of patients showed an association with B8 and B27, which failed to reach clinical significance. This data suggests that the multifactorial inheritance postulated for migraine probably does not require the participation of the HLA-A or B locus of the major histocompatibility complex.

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