Associate Professor of Medicine, University of Toronto, Department of Neurological Sciences, Sunnybrook Medical Center, Toronto.
The Headaches of Ischemic Cerebrovascular Disease†
Article first published online: 23 JUN 2005
Headache: The Journal of Head and Face Pain
Volume 19, Issue 6, pages 345–349, September 1979
How to Cite
Edmeads, J. (1979), The Headaches of Ischemic Cerebrovascular Disease. Headache: The Journal of Head and Face Pain, 19: 345–349. doi: 10.1111/j.1526-4610.1979.hed1906345.x
Presented at the Twenty–first Annual Meeting of the American Association for the Study of Headache, Boston, June 23, 1979.
- Issue published online: 23 JUN 2005
- Article first published online: 23 JUN 2005
- Accepted for Publication: June 23, 1979
- Cited By
It has been suggested that the headaches which frequently precede or accompany transient cerebral ischemic attacks and completed strokes may be produced by dilatation of collateral circulation. This hypothesis was tested in studies of 400 patients in an acute stroke unit. Detailed clinical analysis was made of the headaches that occurred. Cerebral circulation was assessed by various combinations of dynamic technetium brain scans, contrast enhanced CT scans, cerebral angiography, and intracarotid 133 Xenon regional cerebral blood flow studies. Headaches occurred in 25% of the patients, and most had the clinical characteristics of vascular headaches. There was no correlation between headaches and cerebral hyperperfusion or collateral circulation. It is unlikely that simple dilatation of collateral circulation is a cause of the headache of ischemic cerebrovascular disease. Platelet aggregation with release of serotonin, prostaglandins, and other substances is a more probable cause.