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SYNOPSIS

The literature on the use of beta-blocking drugs in migraine suggests that not all such agents are effective. A double-blind crossover study of timolol in migraine prophylaxis was undertaken with fourteen patients, in order to assess the value of this drug in particular, and also to elucidate further the reason for the varied response to different beta-blockers. Timolol significantly reduced the frequency of migraine attacks, and was preferred to placebo. This supports the contention that beta-blocking drugs without intrinsic sympathomimetic activity are effective in migraine prophylaxis.