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SYNOPSIS

Recent evidence has indicated activation of the serum complement system in some migraine sufferers. Using a new accurate method for the determination of C-1 inhibitor in serum, we found an average of 17.33 mgdl (S.D. = 1.82) in 23 normal females. In 23 female migraineurs, the C-1 average value was 17.87 mgdl (S.D. = 2.66). The value in 4 normal males was 18.82 mgdl (S.D. = 2.16) and in 4 male migraineurs 18.34 mgdl (S.D. = 3.36). No correlation of C-1 inhibitor concentration with the type or severity of migraine was identified.