The National Migraine Foundation Lectureship for 1979.
The Biochemistry of Migraine†
Article first published online: 22 JUN 2005
Headache: The Journal of Head and Face Pain
Volume 20, Issue 5, pages 235–246, September 1980
How to Cite
Bruyn, G.W. (1980), The Biochemistry of Migraine. Headache: The Journal of Head and Face Pain, 20: 235–246. doi: 10.1111/j.1526-4610.1980.hed2005235.x
- Issue published online: 22 JUN 2005
- Article first published online: 22 JUN 2005
- Cited By
In the stereotyped, transient and paroxysmal triad of autonomic, vascular and nociceptive dysfunction, precipitated by non-specific factors, known as the migraine attack certain biochemical mediators appear to occupy key-positions in the chain of pathomechanic events occurring at the neural and humoral interface.Of these are reviewed: histamine and serotonin (inhibitory at the microvascular level), substance P and the kinins (excitatory at the nociceptive neural level), tyramine as an a-adrenergic activator, and prostaglandins as humoral agents acting on certain cell-membranes. Anatomical, clinical and biochemical arguments are marshalled to bring the neurogenic origin of the migraine attack into focus, in particular at hypothalamic level.