The Effect of Ergotamine on Prostaglandin Formation in Guinea Pig‘s Ear Slices




We have studied the effect of ergotamine tartrate (10−7 and 10−5 M) on prostaglandin (PG) formation in guinea pig's ear slices because of the suggested role of PGs in the pathophysiology of the migraine attack. The ear slices were incubated with arachidonic acid (AA) and the amount of different PGs (6-keto-F1a, F2a, E2, D2 and A2) in the incubation medium was determined. The results indicate that ergotamine is an inhibitor of PG synthesis and that it probably affects either the phospholipase A2 or the cyclo-oxygenase activity.