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SYNOPSIS

5-Hydroxytryptamine (5-HT) was determined in platelets of 23 patients with muscle contraction headache and the results were compared to those obtained in a control group of 20 healthy persons. 5-HT was observed to be significantly lower in patients with muscle contraction headache as compared to the control group. It is concluded that 5-HT may be involved in peripheral andor central pain mechanisms of muscle contraction headache.