This study was designed to document the clinical observation that oral salt load triggers migraine, and to evaluate angiotensin and aldosterone changes during the headache response.

One gram capsules of sodium chloride or identical gelatin placebos given by mouth to 25 migraine patients and 24 non-migrainous controls resulted in statistically significant elevation of plasma angiotensin levels in those receiving salt compared to those receiving gelatin. Fourteen out of fifteen migraine patients who received salt developed typical migraine headache. Headache occurred in one out of ten migraineurs ingesting gelatin capsules. This difference in induced headache was also statistically significant.