*M.S. in Surgery, F.A.C.S., 310 Jason Central Medical Building, St. Paul, Minnesota 55104.
Angiotensin and Aldosterone Elevation in Salt-induced Migraine
Article first published online: 22 JUN 2005
Headache: The Journal of Head and Face Pain
Volume 21, Issue 5, pages 222–226, September 1981
How to Cite
Brainard, J. B. (1981), Angiotensin and Aldosterone Elevation in Salt-induced Migraine. Headache: The Journal of Head and Face Pain, 21: 222–226. doi: 10.1111/j.1526-4610.1981.hed2105222.x
This study was funded in part through grant MF 78-2-10 under provision of the Minnesota Health Research Program, administered by the Statewide Health Co-Ordinating Council and the State Planning Agency.
- Issue published online: 22 JUN 2005
- Article first published online: 22 JUN 2005
- Cited By
This study was designed to document the clinical observation that oral salt load triggers migraine, and to evaluate angiotensin and aldosterone changes during the headache response.
One gram capsules of sodium chloride or identical gelatin placebos given by mouth to 25 migraine patients and 24 non-migrainous controls resulted in statistically significant elevation of plasma angiotensin levels in those receiving salt compared to those receiving gelatin. Fourteen out of fifteen migraine patients who received salt developed typical migraine headache. Headache occurred in one out of ten migraineurs ingesting gelatin capsules. This difference in induced headache was also statistically significant.