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SYNOPSIS

To establish if other neuromodulators exhibit abnormal metabolism in the platelet during migraine, we sought to analyze taurine levels, a neuromodulator known to be actively accumulated by the platelet. It was found that taurine platelet levels were greater during the headache phase (p<0.01) than the postictal phase. We propose that the metabolic platelet defect in migraine extends beyond a singular chemical species, i.e., serotonin, but may involve other substances such as taurine.