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SYNOPSIS

Prostaglandin E2 (PG-E2) levels were measured in the saliva of 6 women suffering from common migraine, during an attack, and in the interval between attacks; the results obtained were compared to the levels found in a matched control group of healthy women. There was a significant increase in the levels of PG-E2 during migraine attack P<0.05. These results may suggest that PG-E2 takes an important role in the mechanism of migraine.