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SYNOPSIS

Various biochemical determinations were performed on plasma and platelets of unmedicated common migrainous patients, either during crisis or in attack-free intervals. The main change occurring during crisis appears to be a release of dense bodies and a-granules, with a concomitant decrease of platelet serotonin uptake but without important modifications of the platelet metabolism of bioamines. From the data concerning platelet serotonin uptake, a slight platelet defect cannot be excluded. Nevertheless, the role of unidentified plasma factor(s) appears to be much more important in the genesis of the biochemical changes observed during common migraine attack.