In a patient suffering from classical migraine, an unenhanced CT scan done a few hours after a recentepisode of headache revealed a low-density area in the right occipital region. On contrast enhancement, apeculiar high-density lesion surrounded by a large low-density area was seen in the same region. This CTscan abnormality totally disappeared spontaneously within two months. Such lesions have been seen inpatients suffering from epilepsy. The possible pathogenetic mechanism is a localized disruption in theblood-brain barrier during the phase of vasoconstriction. Such a CT scan abnormality in patients sufferingfrom migraine has not been reported earlier.