A female with multiple personality disorder (MPD) was referred for treatment of several different anddistinct headache problems. This case is presented in detail and the literature is reviewed in regard toheadaches occurring in cases of MPD.In an extensive review of 52 previously reported cases of MPD, headaches was the most frequent somaticcomplaint, occurring in over 60%. Headaches previously reported, however, have never been well definedas to etiology, type or treatment. This paper addresses these areas and the problems involved in makingsuch determinations in this unusual personality disorder.The curious clinical observations about the headaches observed in this case of MPD suggest that thisgroup of headache patients might prove to be a unique population for further study, especially in regard tosolving some of the biochemical and emotional mechanisms of headache, and their possible interactions.