A New Immunological Aspect of Cluster Headache: The Increase of Monocyte and NK Cell Populations
Article first published online: 22 JUN 2005
Headache: The Journal of Head and Face Pain
Volume 26, Issue 3, pages 134–136, March 1986
How to Cite
Giacovazzo, M., Martelletti, R., Valeri, M., Piazza, A. and Casciani, C.U. (1986), A New Immunological Aspect of Cluster Headache: The Increase of Monocyte and NK Cell Populations. Headache: The Journal of Head and Face Pain, 26: 134–136. doi: 10.1111/j.1526-4610.1986.hed2603134.x
- Issue published online: 22 JUN 2005
- Article first published online: 22 JUN 2005
- Accepted for Publication: November 4, 1985
- Cited By
Our recent work focused on some immunological aspects of CH patients. We found a decrease in the expression of HLA-B14 antigen on lymphocytes of these patients. In previous studies, we showed that testosterone plasma levels are low in these patients during the crises. It is possible to postulate a correlation between the variation of some hormonal parameter and changes of circulating leukocytes subsets (as in pregnancy and in the pre-eclamptic syndrome).
The following lymphocyte and monocyte subsets were studied using the monoclonal antibodies of Becton Dickinson series: Leu1 +, Leu2+, Leu3a+, Leu7+, Leu10+, ratio helper/ suppressor, LeuM3 +. We compared, using the ANOVA test, the values obtained during a phase of headache crisis versus those obtained out of crisis. A significant increase in lymphocyte subset Leu7+ (20.9±2.5 vs. 13.8±1.1, p<0.05) and in monocyte subset LeuM3 + (26.3 ± 1.4 vs. 20.8 ± 1.2, p<0.05) was observed during the phase of crisis.