Plasma Methionine Enkephalin. Increased Levels During a Migraine Episode

Authors

  • Aron D. Mosnaim Ph.D.,

    1. Department of Pharmacology, University of Health Sciences/The Chicago Medical School, North Chicago, Illinois,
    2. The North Chicago Veterans Administration Medical Center, Chicago, Illinois
    Search for more papers by this author
  • Jorge Chevesich B.S.,

    1. Department of Pharmacology, University of Health Sciences/The Chicago Medical School, North Chicago, Illinois,
    Search for more papers by this author
  • Marion E. Wolf M.D.,

    1. The North Chicago Veterans Administration Medical Center, Chicago, Illinois
    2. Department of Psychiatry, Loyola University, Chicago, Illinois and
    Search for more papers by this author
  • Frederick G. Freitag D.O.,

    1. Diamond Headache Clinic, Chicago, Illinois.
    Search for more papers by this author
  • Seymour Diamond M.D.

    1. Department of Pharmacology, University of Health Sciences/The Chicago Medical School, North Chicago, Illinois,
    2. Diamond Headache Clinic, Chicago, Illinois.
    Search for more papers by this author

  • This work was supported, in part by the National Migraine Foundation, and The School of Graduate and Postdoctoral Studies, The University of Health Sciences.

Abstract

SYNOPSIS

Plasma methionine-enkephalin (MET) levels in migraine patients, either during an attack or when pain-free, are statistically significantly higher than in matched controls; this is also true when comparing the classical and nonclassical migraine subpopulations with the control group. Individual patients consistently presented lower MET plasma concentrations in the pain-free period than during the acute headache, with some subjects showing values falling within the range of controls. Platelet neuropeptide content was similar in patients and controls, irrespective of plasma MET levels. These results indicate that increased plasma MET concentrations are associated with the occurrence of a migraine episode and suggests that they are not a constant characteristic of migraineurs.

Ancillary