This work was supported, in part by the National Migraine Foundation, and The School of Graduate and Postdoctoral Studies, The University of Health Sciences.
Plasma Methionine Enkephalin. Increased Levels During a Migraine Episode
Article first published online: 22 JUN 2005
Headache: The Journal of Head and Face Pain
Volume 26, Issue 6, pages 278–281, June 1986
How to Cite
Mosnaim, A. D., Chevesich, J., Wolf, M. E., Freitag, F. G. and Diamond, S. (1986), Plasma Methionine Enkephalin. Increased Levels During a Migraine Episode. Headache: The Journal of Head and Face Pain, 26: 278–281. doi: 10.1111/j.1526-4610.1986.hed2606278.x
- Issue published online: 22 JUN 2005
- Article first published online: 22 JUN 2005
- Accepted for Publication: April 9, 1986
- Cited By
Plasma methionine-enkephalin (MET) levels in migraine patients, either during an attack or when pain-free, are statistically significantly higher than in matched controls; this is also true when comparing the classical and nonclassical migraine subpopulations with the control group. Individual patients consistently presented lower MET plasma concentrations in the pain-free period than during the acute headache, with some subjects showing values falling within the range of controls. Platelet neuropeptide content was similar in patients and controls, irrespective of plasma MET levels. These results indicate that increased plasma MET concentrations are associated with the occurrence of a migraine episode and suggests that they are not a constant characteristic of migraineurs.