Early Morning Headache of Parkinson's Disease: A Hitherto Unrecognized Symptom?




Reported in this paper are three cases of Parkinson's disease in which early morning headache occurred in coincidence with early morning akinesia. The common points found in the three cases were: (1) headache is relieved as Parkinsonian symptoms are improved by L-dopa; (2) short duration improvement is remarkable; (3) early morning akinesia is marked; and (4) the pain relieving effect of L-dopa given at midnight is invariably found. It appeared that in further studies on early morning headache in Parkinson's disease the relation of the headache to the pathophysiology of brain neuropeptides including b-endorphin should be investigated.