The purpose of this controlled study was to compare anger experience, anger-relevant psychophysiological parameters, and expressive anger behavior of migraine patients, with those of pain patients and of healthy controls. Based on the probability of solving anagram tasks, we defined an anger-provoking condition and a control condition. Data from 72 female subjects were used for analysis. Migraine patients showed a deficit in open anger behavior; their diastolic blood pressure decreased and their pulse pressure (SBP-DBP) was higher compared to the two control groups. They did not differ with respect to their self-reported anger experience.