Prophylaxis of Migraine with Anionic Polyelectrolytes
Article first published online: 22 JUN 2005
Headache: The Journal of Head and Face Pain
Volume 28, Issue 2, pages 114–120, March 1988
How to Cite
Thonnard-Neumann, E. and Bigelow, L. B. (1988), Prophylaxis of Migraine with Anionic Polyelectrolytes. Headache: The Journal of Head and Face Pain, 28: 114–120. doi: 10.1111/j.1526-4610.1988.hed2802114.x
- Issue published online: 22 JUN 2005
- Article first published online: 22 JUN 2005
- Accepted for Publication: December 10, 1987
- Cited By
In previous studies on patients with migraine headaches we found that 50% had reduced concentrations of basophils and lymphocytes. Treatment with inhalations of heparin often restored these blood indices to normal and was accompanied by a reduction in migraine headache, We report here data on the long term treatment of 37 migraine patients with inhalations of heparin and with an oral semi-synthetic heparinoid, Pentosan Polysulfate (PNP). 27 patients responded with a mean improvement in migraine index of 79% and as a group showed significant increases in basophil, total lymphocyte, and in particular T-cell concentrations.
Ten patients whose migraine headaches were related to their menstrual cycles were relatively unresponsive to heparin or PNP. They had a general leukopenia, but basophils were within normal range.