The recurrent or cyclic time pattern is one of the most characteristic features of the Cluster Headache (CH) syndrome.

This observation has led to many studies which have proposed that the central hypothalamic system possibly plays a role in the pathogenesis of Cluster Headache attacks.

In this study we utilized the Dexamethasone Suppression Test in order to test the functioning of the hypothalamo-pituitary axis in CH patients, in the headache-free state.

We were able to ascertain that the hypothalamo-pituitary axis functioned normally, while the base-line cortisol levels of Cluster Headache patients appeared higher than the levels found in the control subjects.