Cardiac Murmurs Indicative of Aortic Valve Disease with Chronic and Excessive Intake of Ergotamine


  • Egilius L. H. Spierings M.D., Ph.D.

    1. The Headache Research Foundation and John R. Graham Headache Centre, The Faulkner Hospital, Boston, Massachusetts, U.S.A.; and
    2. Department of Neurology, Tufts University School of Medicine, Boston, Massachusetts, U.S.A.
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Two patients are reported who developed cardiac murmurs indicative of aortic valve disease during chronic and excessive intake of ergotamine. Ergotamine is an antimigraine medication chemically related to methysergide of which endocardial fibrosis is a rare but well-established side-effect.