Presented at the XXV Congress of the Italian Neurological Society, Bologna, 1987.
Mitochondrial Abnormalities in Migraine. Preliminary Findings.†
Article first published online: 22 JUN 2005
Headache: The Journal of Head and Face Pain
Volume 28, Issue 7, pages 477–480, August 1988
How to Cite
Montagna, P., Sacquegna, T., Martinelli, P., Cortelli, P., Bresolin, N., Moggio, M., Baldrati, A., Riva, R. and Lugaresi, E. (1988), Mitochondrial Abnormalities in Migraine. Preliminary Findings. Headache: The Journal of Head and Face Pain, 28: 477–480. doi: 10.1111/j.1526-4610.1988.hed2807477.x
- Issue published online: 22 JUN 2005
- Article first published online: 22 JUN 2005
- Accepted for publication: June 10, 1988.
- Cited By
Nine patients with migraine (5 with migraineous stroke) were investigated for defects of mitochondrial energy metabolism. During effort, blood lactate rose significantly higher in migraineurs. Muscle biopsy showed ragged-red fibres deficient in cytochrome-c-oxidase activity in one case. On muscle biochemistry, depression of some respiratory chain enzymes was found for the whole group of patients, and especially in 2 for cytochrome-c-oxidase, succinate-cytochrome-c-reductase and NADH-cytochrome-c-reductase.
Our findings are still preliminary, but they suggest impaired mitochondrial energy metabolism in migraine.