Mitochondrial Abnormalities in Migraine. Preliminary Findings.


  • Presented at the XXV Congress of the Italian Neurological Society, Bologna, 1987.



Nine patients with migraine (5 with migraineous stroke) were investigated for defects of mitochondrial energy metabolism. During effort, blood lactate rose significantly higher in migraineurs. Muscle biopsy showed ragged-red fibres deficient in cytochrome-c-oxidase activity in one case. On muscle biochemistry, depression of some respiratory chain enzymes was found for the whole group of patients, and especially in 2 for cytochrome-c-oxidase, succinate-cytochrome-c-reductase and NADH-cytochrome-c-reductase.

Our findings are still preliminary, but they suggest impaired mitochondrial energy metabolism in migraine.