Adverse Reactions to Iopamidol and Iohexol Myelography with Special Attention to Headache: Role of Myelographic Technique


  • David F. Sobel M.D.,

    1. Scripps Clinic and Research Foundation, Department of Radiology, 10666 North Torrey Pines Road, La Jolla, California 92037.
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  • Rekarda Rowe R.N., B.S.N.,

  • Jack Zyroff M.D.,

  • James A. Koziol Ph.D.,

    1. Department of Molecular and Experimental Medicine.
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  • Francine Frost R.N., B.S.N.,

  • Jean Krupsaw R.N.

  • This research was supported in part by NIH grant RR00833 to the General Clinical Research Center at Scripps Clinic and Research Foundation.



In order to identify those myelographic risk factors associated with a higher incidence of adverse effects, myelographic technique, patient variables and post-myelographic symptoms were prospectively recorded in a group of 152 patients studied with iopamidol and in a second group of 28 patients studied with iohexol.

None of the technical factors studied were identified to have a statistically significant relationship with the incidence of adverse reactions. Older patients fared better than younger patients in both groups. Overall, there was a lower incidence of side effects in the iopomidol group (29%) than in the iohexol group (50%). Headache, nausea, and vomiting were the most frequent reactions seen.