Low Brain Magnesium in Migraine


  • This paper is the winner of the 1989 Harold G. Wolff Award.

  • Supported in part by NIH grant #NS23393 (to K.M.A.W.) and Henry Ford Hospital.



Brain magnesium was measured in migraine patients and control subjects using in vivo 31-PhosphorusNuclear Magnetic Resonance Spectroscopy, pMg and pH were calculated from the chemical shifts between Pi, PCr and ATP signals. Magnesium levels were low during a migraine attack without changes in pH. We hypothesize that low brain magnesium is an important factor in the mechanism of the migraine attack.