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SYNOPSIS

Brain magnesium was measured in migraine patients and control subjects using in vivo 31-PhosphorusNuclear Magnetic Resonance Spectroscopy, pMg and pH were calculated from the chemical shifts between Pi, PCr and ATP signals. Magnesium levels were low during a migraine attack without changes in pH. We hypothesize that low brain magnesium is an important factor in the mechanism of the migraine attack.