Migraine With and Without Aura: The Same Disease Due to Cerebral Vasospasm of Different Intensity. A hypothesis based on CBF studies during migraine.
Article first published online: 20 MAY 2005
Headache: The Journal of Head and Face Pain
Volume 30, Issue 5, pages 269–272, April 1990
How to Cite
Olsen, T. S. (1990), Migraine With and Without Aura: The Same Disease Due to Cerebral Vasospasm of Different Intensity. A hypothesis based on CBF studies during migraine. Headache: The Journal of Head and Face Pain, 30: 269–272. doi: 10.1111/j.1526-4610.1990.hed3005269.x
- Issue published online: 20 MAY 2005
- Article first published online: 20 MAY 2005
- Accepted for Publication: January 31, 1990.
- Cited By
The CBF studies performed so far during attacks of migraine, may be interpreted as favouring “the vascular theory.” This applies to migraine with aura as well as to migraine without aura. Migraine without aura may be due to mild focal CBF reduction - too mild to be detected by the available CBF techniques (i.e. 20% or less) and too mild to produce ischemia and aura phenomena. Migraine with aura may be due to focal CBF reduction severe enough to produce ischemia (i.e. 50% or more) and therefore also aura phenomena.
The phenomenon termed “spreading oligemia” typically seen in CBF studies during migraine with aura, may be an artifact reflecting a gradual decrease of CBF in an area of constant size. The typical “march” of the aura symptoms may reflect differences in the ischemic threshold of various neurones leading to dysfunction of more and more neurones as the blood flow gradually decreases.
It is concluded that migraine with and without aura may be due to the same disease process-the only difference being the intensity of vasospasm and CBF reduction.