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SYNOPSIS

Available evidence supports the contention that migraine involves a disturbance in serotonin function.Several parameters of serotonin function in humans have been found to vary seasonally and may underliethe seasonal fluctuations observed in many clinical neuropsychiatric phenomena that are thought toinvolve serotonin dysfunction. We therefore postulated that migraine headaches might also varyseasonally and examined the admissions to our hospital over a 20-year period with a primary diagnosis ofmigraine. Peak admissions were found to occur most frequently in the spring for females in comparison tomales (p£0.04, chi-square). The implications of these findings are discussed.