Acetylsalicylic Acid vs. Metoprolol in Migraine Prophylaxis - A Double-Blind Cross-Over Study
Article first published online: 20 MAY 2005
Headache: The Journal of Head and Face Pain
Volume 30, Issue 10, pages 639–641, October 1990
How to Cite
Grotemeyer, K.-H., Scharafinski, H.-W., Schlake, H.-P. and Husstedt, I. (1990), Acetylsalicylic Acid vs. Metoprolol in Migraine Prophylaxis - A Double-Blind Cross-Over Study. Headache: The Journal of Head and Face Pain, 30: 639–641. doi: 10.1111/j.1526-4610.1990.hed3010639.x
- Issue published online: 20 MAY 2005
- Article first published online: 20 MAY 2005
- Accepted for Publication: August 26, 1990.
- Cited By
In a double blind cross-over study, 28 patients, 5 male and 23 female, aged 31 ± 14 years, after a run-in period of 8 weeks, were treated for 3 months with acetylsalicylic acid and for another 3 months with metoprolol, both in a prophylactic mode. Attack frequency was reduced significantly with both therapeutic regimens (ASA p<0.001, metoprolol p<0.00005). Reduction of attacks below 50% was seen with metoprolol in 14 cases, and with ASA in three cases. Even though ASA was of statistically significant efficacy in migraine prophylaxis, it clearly is not the drug of first choice in migraine prophylaxis.