Associate Professor of Neurology, Temple University School of Medicine, Philadelphia, Pennsylvania
Claudication: An Unusual Side Effect of DHE Administration
Version of Record online: 20 MAY 2005
Headache: The Journal of Head and Face Pain
Volume 31, Issue 4, pages 237–239, April 1991
How to Cite
Schulman, E. A. and Rosenberg, S. B. (1991), Claudication: An Unusual Side Effect of DHE Administration. Headache: The Journal of Head and Face Pain, 31: 237–239. doi: 10.1111/j.1526-4610.1991.hed3104237.x
- Issue online: 20 MAY 2005
- Version of Record online: 20 MAY 2005
- Accepted for Publication: March 4, 1991
- Cited By
DHE is effective in the treatment of acute and chronic migraine. The side effects most commonly observed are abdominal discomfort, muscle pain, diarrhea and anxiety.
DHE is a dehydrogenated amino acid ergot alkaloid and, as such, causes only limited vasoconstriction; indeed, its overall effects include peripheral vasodilatation.
The literature is replete with reports of clinical vasospasm and claudication occurring with therapeutic doses of ergotamine. There has not been any previous description of claudication caused by DHE.
This paper describes pulselessness in two patients during relatively short courses of DHE. Treatment consisted of calcium channel blockers and discontinuation of DHE. Recovery was complete.