Solved and Unsolved Headache Problems

John Graham Senior Clinicians Forum


  • James W. Lance

    1. Institute of Neurological Sciences, The Prince Henry and Prince of Wales Hospital, Sydney, Australia and
    2. The University of New South Wales, Sydney, Australia.
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Two unusual cases of vascular headache, one caused by jugular venous compression from a goiter and one triggered by flushing associated with a CGRP-producing renal tumour, are reported. Their histories are compared with those experiencing other headaches of vascular origin. Two patients with a primary neural irritative lesion, one with a sphenoid sinus carcinoma and one with Tolosa-Hunt syndrome, presented with headaches resembling migraine. These case-histories are used to illustrate the interaction of nervous system and vascular system in the production of headache which has implications for the pathophysiology of migraine and cluster headache.