Myocardial Ischemia Related to Ergot Alkaloids: A Case Report and Literature Review
Article first published online: 20 MAY 2005
Headache: The Journal of Head and Face Pain
Volume 31, Issue 7, pages 446–450, July 1991
How to Cite
Galer, B. S., Lipton, R. B., Solomon, S., Newman, L. C. and Spierings, E. L.H. (1991), Myocardial Ischemia Related to Ergot Alkaloids: A Case Report and Literature Review. Headache: The Journal of Head and Face Pain, 31: 446–450. doi: 10.1111/j.1526-4610.1991.hed3107446.x
- Issue published online: 20 MAY 2005
- Article first published online: 20 MAY 2005
- Accepted for Publication: April 30, 1991.
- Cited By
Ergotamine tartrate and methysergide are widely used headache treatments with important vasoconstrictive properties. We report a 31-year-old man with cluster headaches who developed severe, prolonged myocardial ischemia following combination therapy with ergotamine tartrate and methysergide. We reviewed the cardiovascular complications of each agent alone and in combination. Given the pharmacologic similarity of these agents, we propose that they may have additive or synergistic cardiac toxicity, at least in vulnerable individuals. We recommend caution when these agents are used together.