Hypothesis: Serotonin-1C Receptor Activation in Migraine: An Alternative Point of View With Therapeutic Implication
Version of Record online: 20 MAY 2005
Headache: The Journal of Head and Face Pain
Volume 31, Issue 8, pages 546–549, September 1991
How to Cite
Spierings, E. L.H. (1991), Hypothesis: Serotonin-1C Receptor Activation in Migraine: An Alternative Point of View With Therapeutic Implication. Headache: The Journal of Head and Face Pain, 31: 546–549. doi: 10.1111/j.1526-4610.1991.hed3108546.x
- Issue online: 20 MAY 2005
- Version of Record online: 20 MAY 2005
- Accepted for Publication: May 25, 1991.
- Cited By
- serotonin-1C receptor;
Brewerton's observation that meta-chlorophenylpiperazine, the major metabolite of trazodone, with high affinity and intrinsic activity for the serotonin-1C receptor precipitates migraine headaches in subjects with a personal and/or family history of migraine, prompted Fozard and Gray to postulate that activation of serotonin-1C receptors plays a significant role in the initiation of the attack. Little note was taken, however, of the significant delay between administration of meta-chlorophenylpiperazine and the onset of the headaches. This delay prompts another hypothesis, that the vasoconstrictive action of this substance, as it wears off leads to rebound vasodilation, precipitating migraine. Under this hypothesis, specific sero-tonin-1C receptor activation is not a necessary condition for the genesis of the migraine attack. As a practical corollary, the vasoconstrictive effect of meta-chlorophenylpiperazine may have therapeutic potential.