Transcranial Doppler (TCD) After Nitroglycerin in Migraine Without Aura




Nitroglycerin, a vasodilating agent, was administered sublingually in migraine without aura patients andin healthy volunteers. Systolic, diastolic and time-mean flow velocity and pulsatility index, were measuredby transcranial Doppler sonography in the major intracranial arteries before and after nitroglycerinadministration. Following nitroglycerin administration, a significant decrease in systolic and time-meanvelocity and pulsatility index was observed in migraine patients, whereas in control subjects onlytime-mean velocity decreased significantly. Based on those findings we hypothesize a more markedresponsiveness to nitroglycerin in migraine patients as compared to healthy subjects.