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Keywords:

  • flunarizine;
  • migraine

SYNOPSIS

Flunarizine, a calcium channel blocker is considered useful in migraine prophylaxis. We report the first Indian trial with thisdrug. Fifteen patients with migraine were studied in a 6 months double-blind, placebo-controlled crossover trial. Flunarizinewas superior to placebo in reducing the severity and duration of the individual attacks though there was no statisticallysignificant effect on frequency of migraine attacks. The side effects most frequently caused by flunarizine were weight gainand daytime sleepiness.