Treatment of Acute Migraine Attack With Diclofenac Sodium: A Double-Blind Study
Article first published online: 19 MAY 2005
Headache: The Journal of Head and Face Pain
Volume 32, Issue 2, pages 98–100, February 1992
How to Cite
Karachalios, G. N., Fotiadou, A., Chrisikos, N., Karabetsos, A. and Kehagioglou, K. (1992), Treatment of Acute Migraine Attack With Diclofenac Sodium: A Double-Blind Study. Headache: The Journal of Head and Face Pain, 32: 98–100. doi: 10.1111/j.1526-4610.1992.hed3202098.x
- Issue published online: 19 MAY 2005
- Article first published online: 19 MAY 2005
- Acepted for Publication: September 26, 1991.
- Cited By
- diclofenac sodium;
- acute migraine;
- prostaglandin synthetase inhibito
The efficacy of diclofenac sodium, a potent prostaglandin inhibitor, in patients with acute migraine attacks in a double-blind placebo-controlled study involving 86 migraine patients.
Forty-six patients with acute migraine attacks were treated with intramuscular injection of 75 mg diclofenac sodium, and another group of forty patients with intramuscular injection of paracetamol.
Partial or complete relief of pain and other symptoms of acute migraine attack was achieved within 10 minutes after treatment in the diclofenac sodium group and within 32 minutes in the paracetamol group.
Complete relief of attack was achieved within 30 minutes after diclofenac sodium in 40 patients (88%) compared to 7 patients (17.5%) of the paracetamol group (P<0,001). Five of the patients treated with diclofenac sodium needed a second injection for complete relief of pain during the 2-to-4 hour follow-up period. Side effects were rare and minimal.
In conclusion, diclofenac sodium administered intramuscularly is a very effective drug in treating acute migraine attacks.