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Keywords:

  • Flunarizine;
  • migraine;
  • headache

SYNOPSIS

We evaluated the effect of flunarizine (Fz) (10 mg/d) on migraine in e double-blind placebo-controlled design. The attacks' frequency, duration, severity and associated symptoms were compared before and after treatment. Forty-two patients completed a three-month trial period; 21 patients received Fz and 21 placebo, Statistical analysis showed no significant difference between Fz and placebo (p>0.051. In this study Fz was not more efficient than placebo in migraine.