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Keywords:

  • migraine;
  • diet;
  • cytokines;
  • neuroimmune networ

SYNOPSIS

This investigation is devoted to the study of the time-course of a cytokines panel (IL-4, IL-6, IFN-gamma,GM-CSF) in plasma samples from migraine patients. The data obtained during challenged migraine crises was compared to the baseline values. Time-data series analysis showed a fall after a challenge test for IL-4 and IL-6 plasma levels and an opposite trend for gamma-IFN and GM-CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possibly be an activation of this cytokine network together with the well-known impairment in the neuropeptidergic system, consideringthe close links between interleukins and other cytokines and the neuro-mediators of pain, such ashistamine and 5-HT.