Increased 11-dehydrothromboxane B 2 in Migraine: Platelet Hyperfunction in Patients with Migraine during Headache-free Period


Ayumi Kitano, M.D., Division of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, 86 Nishimachi, Yonago, 683, Japan.



Several disturbances in platelet function have been reported in migraine and tension-type headache (TH). The plasma 11-dehydrothromboxane B 2 (11-dTXB 2 ) is free from artifactual increase during blood sampling, and it can be a reliable indicator of thromboxane A 2 (TXA 2 ) production in vivo. TXA 2 is a very potent proaggregatory and vasoconstrictory metabolite formed in the platelets. We investigated plasma 11-dTXB 2 and 5-hydroxytryptamine (5-HT) levels in patients with migraine during headache-free periods and in patients with chronic TH. The mean value of plasma 11 -dTXB 2 levels in migrainous patients was significantly higher than those in TH patients and healthy controls. The mean value of plasma 5-HT levels in TH patients was significantly lower than those in migrainous patients and healthy controls. There was no correlation between plasma 11-dTXB 2 levels and plasma 5-HT levels in any group. The results suggest the existence of continuous platelet activation in migrainous patients.