Dopamine Hypersensitivity in Migraine: Role in Apomorphine Syncope


Prof. Maria Del Zompo, Department of Neurosciences “B.B. Brodie”, University of Cagliari, via Porcell 4, 09124 Cagliari, Italy.


There is some evidence supporting a potential role of hypersensitivity of the dopaminergic system in the pathogenesis of migraine. In this case report, we describe a syncopal episode in a patient with migraine without aura after the administration of a very low dose of apomorphine, a classical agonist of dopaminergic receptors. The absence of cardiovascular risk factors in this patient suggests that the clinical event might have been caused by hypersensitivity of the dopaminergic system.