Eletriptan for the Short-term Prophylaxis of Cluster Headache
Article first published online: 13 APR 2004
Headache: The Journal of Head and Face Pain
Volume 44, Issue 4, pages 361–364, April 2004
How to Cite
Zebenholzer, K., Wöber, C., Vigl, M. and Wessely, P. (2004), Eletriptan for the Short-term Prophylaxis of Cluster Headache. Headache: The Journal of Head and Face Pain, 44: 361–364. doi: 10.1111/j.1526-4610.2004.04079.x
- Issue published online: 13 APR 2004
- Article first published online: 13 APR 2004
- Accepted for publication January 13, 2004.
- cluster headache;
Background.—A beneficial prophylactic effect from eletriptan 40 mg given to a single patient with cluster headache was observed.
Objective.—To further evaluate the efficacy of eletriptan in the short-term prophylaxis of cluster headache.
Methods.—We treated 18 patients; mean age, 40.5 years (standard deviation [SD], 9.9). The number of cluster headache attacks was recorded during a baseline period of 6 days, and during 6 days of treatment with eletriptan 40 mg twice daily. The primary outcome measure was the reduction in the number of attacks during the treatment period.
Results.—In the 16 patients who completed the study (2 patients were lost to follow-up), the mean total number of attacks decreased from 10.9 (SD, 5.6) during baseline to 6.3 (SD, 3.7) during treatment with eletriptan (P= .01) The reduction in the number of attacks exceeded 50% in 6 patients.
Conclusion.—This small open-label study suggests that eletriptan 40 mg twice daily may be useful for the short-term prophylaxis of cluster headache.