From the Department of Neurology, Catholic University of Korea, Seoul, Republic of Korea (Jeong Wook Park, Joong Seok Kim, Yeong In Kim, Kwang Soo Lee) and the Department of Psychiatry, Catholic University of Korea, Seoul, Republic of Korea (Hae Kook Lee).
Serotonin Transporter Polymorphism and Harm Avoidance Personality in Chronic Tension-Type Headache
Article first published online: 10 NOV 2004
Headache: The Journal of Head and Face Pain
Volume 44, Issue 10, pages 1005–1009, November 2004
How to Cite
Park, J. W., Kim, J. S., Lee, H. K., Kim, Y. I. and Lee, K. S. (2004), Serotonin Transporter Polymorphism and Harm Avoidance Personality in Chronic Tension-Type Headache. Headache: The Journal of Head and Face Pain, 44: 1005–1009. doi: 10.1111/j.1526-4610.2004.04194.x
- Issue published online: 10 NOV 2004
- Article first published online: 10 NOV 2004
- Accepted for publication June 23, 2004.
- serotonin transporter protein;
- harm avoidance;
- chronic tension-type headache;
- promoter polymorphism
Objective.—To investigate the 5-HTT-gene-linked polymorphic region (5-HTTLPR) genotypes and harm avoidance (HA) dimension in chronic tension-type headache (CTH).
Background.—Serotonin transporter protein (5-HTT) is a key modulating protein in synaptic serotonergic neurotransmission. Among serotonin gene-linked polymorphism, promoter located in the regulatory region of the 5-HTTLPR has two alleles (short and long) with different transcriptional efficiencies. The HA personality trait may be heritable and associated with serotonergic neurotransmitter activity.
Design.—We amplified the 5-HTTLPR by means of polymerase chain reaction and performed genotype polymorphism analyses and we investigated the serotonin-related personality trait by evaluating the HA dimension in tridimensional personality questionnaire (TPQ) in 107 patients with CTH and in 100 healthy controls.
Results.—We found an excess frequency of the short allele and a different genotype distribution in patients with CTH. S/S genotype frequency was significantly higher in patients with CTH (76%) than in those with controls (59%; P= .02). Patients with CTH had significantly higher HA scores (21.4 ± 6.3) than controls (16.3 ± 6.1).
Conclusions.—This suggests a serotonergic activity might be involved in the development of CTH and 5-HTTLPR might be one of the genetically contributing factors.