From Dubai Police Medical Services, Dubai, United Arab Emirates.
Recurrent Syncope, Hypotension, Asthma, and Migraine With Aura: Role of Metoclopramide
Version of Record online: 1 NOV 2005
Headache: The Journal of Head and Face Pain
Volume 45, Issue 10, pages 1413–1415, November 2005
How to Cite
Gupta, V. K. (2005), Recurrent Syncope, Hypotension, Asthma, and Migraine With Aura: Role of Metoclopramide. Headache: The Journal of Head and Face Pain, 45: 1413–1415. doi: 10.1111/j.1526-4610.2005.00276_2.x
- Issue online: 1 NOV 2005
- Version of Record online: 1 NOV 2005
- Accepted for publication May 17, 2005.
- arginine vasopressin
Migraine associated with asthma or symptomatic orthostatic hypotension is a particularly difficult subgroup to manage. Metoclopramide is a useful pharmacological agent for orthostatic hypotension. I present the case report of a migraine patient with asthma and recurrent hypotensive syncope. Metoclopramide relieved recurrent syncope as well as migraine attacks in this patient. Metoclopramide has a striking influence on arginine vasopressin (AVP) secretion. AVP promotes antinociception and influences vasomotor and behavior control, which actions possibly keep migraine in remission. Further studies are necessary to confirm the migraine prophylactic value of metoclopramide.