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Intracranial Hypertension Induced by Rofecoxib


  • Saiju Jacob MD, MRCP,

  • Yusuf A. Rajabally MD

  • From the University Hospitals of Leicester, Neurology, Leicester United Kingdom, (Drs. Jacob and Rajabally).

Address all correspondence to Dr. Saiju Jacob, University Hospitals of Leicester, Neurology, Leicester, United Kingdom.


Several secondary causes are implicated in the etiology of idiopathic intracranial hypertension. Rofecoxib is a selective cyclo-oxygenase (COX)-2 inhibitor, now being increasingly used in place of nonselective nonsteroidal anti-inflammatory drugs (NSAIDs). We report a case of intracranial hypertension in a 69-year-old man 3 weeks after the commencement of rofecoxib therapy with reversal of clinical findings on drug withdrawal.