From the Utrecht Institute for Pharmaceutical Sciences, Pharmacoepidemiology and Pharmacotherapy, Utrecht, The Netherlands (Drs. Wammes-van der Heijden and Egberts); Department of Neurology, St. Elisabeth Hospital, Tilburg, The Netherlands (Drs. Smidt and Tijssen); Thrombosis Services Midden-Brabant, Tilburg, The Netherlands (Dr. van ‘t Hoff); and TweeSteden Hospital and St. Elisabeth Hospital, Hospital Pharmacy Midden-Brabant, Tilburg, The Netherlands (Drs. Lenderink and Egberts).
Effect of Low-Intensity Acenocoumarol on Frequency and Severity of Migraine Attacks
Article first published online: 10 FEB 2005
Headache: The Journal of Head and Face Pain
Volume 45, Issue 2, pages 137–143, February 2005
How to Cite
Wammes-van der, E. A., PharmD, H., Smidt, M. H., Tijssen, C. C., Van‘t Hoff, A. R., Lenderink, PharmD, A. W. and Egberts, PharmD, A. C.G. (2005), Effect of Low-Intensity Acenocoumarol on Frequency and Severity of Migraine Attacks. Headache: The Journal of Head and Face Pain, 45: 137–143. doi: 10.1111/j.1526-4610.2005.05028.x
Major bleeding complications are usual defined as intracranial hemorrhage, bleedings that cause death, that require blood transfusion, admission to a hospital or surgery, and all muscle and joint bleedings.
- Issue published online: 10 FEB 2005
- Article first published online: 10 FEB 2005
- Accepted for publication July 5, 2004.
- migraine prophylaxis
Objective.—To investigate the effect of low-intensity acenocoumarol treatment (target INR 1.5 to 2.0) on the frequency and severity of migraine attacks.
Background.—The positive effect of anticoagulation on migraine has been described in case reports and observational studies.
Methods.—We conducted a randomized, open, crossover study in migraine patients. After a run-in period of 8 weeks, all patients received acenocoumarol or propranolol during a period of 12 weeks and, after a washout period of 2 weeks, propranolol or acenocoumarol during a second period of 12 weeks.
Results.—Nineteen patients fulfilling the criteria were included. In 12 patients with complete data collection, only one good responder could be noted. In the other patients, treatment with low-intensity acenocoumarol did not show improvement of migraine symptoms compared with the run-in period. Treatment with propranolol showed a trend towards improvement compared with the run-in period. No serious adverse events were observed.
Conclusions.—Overall, low-intensity acenocoumarol treatment has no prophylactic effect in migraine patients.