Botox Therapy for Refractory Chronic Migraine


  • Stafford Conway MD,

  • Curtis Delplanche MD,

  • Jessica Crowder MD,

  • John Rothrock MD

  • From the University of South Alabama Headache Center, Mobile, AL.

Address all correspondence to Dr. John F. Rothrock, University of South Alabama Headache Center, 3401 Medical Park Drive, Building 3, Suite 205, Mobile, AL 36693.


Chronic migraine is unfortunately both common and often resistant to treatment even with prophylactic medications known to be effective in populations with episodic migraine. We undertook an open-label study to evaluate the safety and utility of botulinum toxin type A injection therapy for patients with chronic migraine who previously had failed to respond to at least three prophylactic medications.